Action of topical dorzolamide 2% solution as an ocular hipotensive. Experimental study in dogs

Abstract

The increasing of intraocular pressure
(IOP) is the major risk factor for the development of
glaucoma. Dorzolamide is used for the treatment of
glaucoma. The aim of this work was to evaluate the
efficacy of 2% solution dorzolamide on IOP of healthy
dogs. Twenty adult dogs received topical treatment in the
left eye with 2% dorzolamide. IOP measurements were
carried out using aplanation tonometry (Tono-penâ).
Measurements were performed 1 hour before instillation
of a single drop of the dorzolamide in the left eye, and at
1, 2, 4, 6 and 8 hours after treatment. In the no treated
eye, IOP decreased over time, with a maximum decrease
from baseline of 13,8%. In the treated eye, there was a
reduction of 22,4%. It was concluded that 2% dorzolamide
is effective to reduce IOP in healthy dogs.