Action of topical dorzolamide 2% solution as an ocular hipotensive. Experimental study in dogs
DOI:
https://doi.org/10.5380/avs.v11i1.5626Keywords:
Cão, pressão intra-ocular, glaucoma, dorzolamida, Dog, intraocular pressure, dorzolamideAbstract
The increasing of intraocular pressure (IOP) is the major risk factor for the development of glaucoma. Dorzolamide is used for the treatment of glaucoma. The aim of this work was to evaluate the efficacy of 2% solution dorzolamide on IOP of healthy dogs. Twenty adult dogs received topical treatment in the left eye with 2% dorzolamide. IOP measurements were carried out using aplanation tonometry (Tono-penâ). Measurements were performed 1 hour before instillation of a single drop of the dorzolamide in the left eye, and at 1, 2, 4, 6 and 8 hours after treatment. In the no treated eye, IOP decreased over time, with a maximum decrease from baseline of 13,8%. In the treated eye, there was a reduction of 22,4%. It was concluded that 2% dorzolamide is effective to reduce IOP in healthy dogs.
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