GASTRIC CARCINOMA WITH OSSEOUS METAPLASIA IN A DOG

Authors

  • Irina Ferraz Amorim Instituto de Ciências Biomédicas de Abel Salazar da Universidade do Porto (ICBAS-UP)
  • Celia Lopes ICBAS-UP
  • Rui M Gil da Costa ICBAS-UP
  • Augusto MR Faustino ICBAS-UP
  • Fatima Gartner Instituto de Patologia e Imunologia da Universidade do Porto (IPATIMUP) e Instituto de Ciências Biomédicas de Abel Salazar (ICBAS-UP)
  • Patricia Dias Pereira ICBAS-UP

DOI:

https://doi.org/10.5380/avs.v17i3.22798

Keywords:

Canine, bone morphogenetic proteins (BMPs), gastric carcinoma, immunohistochemistry, osseous metaplasia

Abstract

This report describes an unprecedented case of a gastric carcinoma with osseous metaplasia in a 8-year-old male standard poodle. An exploratory laparotomy revealed a firm yellowish nodular mass in the pyloric region. The lesion was surgically removed and submitted for current histological examination. Immunohistochemistry was performed employing monoclonal antibodies for pan-cytokeratin, vimentin, smooth muscular a-actin and BMP-2/4. The mass consisted in neoplastic proliferation of epithelial cells, arranged in a tubular or acinar pattern and supported by scirrhous stroma, with mucin production and multiple foci of heterotopic ossification. Neoplastic epithelial cells showed strong positive immunostaining for AE1/AE3 and BMP-2/4, although they were negative for both vimentin and a-actin. Histopathological findings suggested that the bone tissue may be primarily originated from neoplastic epithelial cells which directly circumscribe the osseous metaplasia foci.

Author Biographies

Irina Ferraz Amorim, Instituto de Ciências Biomédicas de Abel Salazar da Universidade do Porto (ICBAS-UP)

Departamento de Patologia e Imunologia Molecular Anatomia Patológica e Pat

Celia Lopes, ICBAS-UP

Rui M Gil da Costa, ICBAS-UP

Augusto MR Faustino, ICBAS-UP

Fatima Gartner, Instituto de Patologia e Imunologia da Universidade do Porto (IPATIMUP) e Instituto de Ciências Biomédicas de Abel Salazar (ICBAS-UP)

Patricia Dias Pereira, ICBAS-UP

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Published

2012-08-01

How to Cite

Amorim, I. F., Lopes, C., Gil da Costa, R. M., Faustino, A. M., Gartner, F., & Dias Pereira, P. (2012). GASTRIC CARCINOMA WITH OSSEOUS METAPLASIA IN A DOG. Archives of Veterinary Science, 17(3). https://doi.org/10.5380/avs.v17i3.22798

Issue

Vol. 17 No. 3 (2012)

Section

Preventive Veterinary Medicine

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