Emerging Fungal Pathogens in Wildlife: a systematic review of Veterinary Implications and One Health Challenges
DOI:
https://doi.org/10.5380/avs.v31i1.101497Palavras-chave:
emerging mycoses, wildlife health, One Health, veterinary diagnostics, fungal pathogens.Resumo
Emerging fungal pathogens represent a growing threat to global biodiversity, animal health, and public health, particularly in wildlife populations where outbreaks can lead to significant ecological and veterinary consequences. This review aims to synthesize current knowledge on the diversity, epidemiology, and pathogenic mechanisms of emerging fungi affecting wild species, while exploring their implications for veterinary medicine and One Health. A comprehensive literature search was conducted across major scientific databases for studies published between 2000 and 2025, focusing on fungal pathogens in wildlife, diagnostic challenges, host–pathogen interactions, and environmental drivers of disease emergence. Key examples include Batrachochytrium dendrobatidis in amphibians, Pseudogymnoascus destructans in bats, and Paranannizziopsis spp. in reptiles, which collectively highlight how environmental change, anthropogenic activity, and global trade facilitate the spread and evolution of pathogenic fungi. These infections often present diagnostic difficulties due to nonspecific clinical signs, require advanced molecular and histopathological tools for confirmation, and frequently demand multidisciplinary management strategies. From a One Health perspective, emerging mycoses in wildlife not only disrupt ecosystems but also pose zoonotic and conservation challenges, emphasizing the need for enhanced surveillance, intersectoral collaboration, and integrative research approaches. By consolidating current evidence, this review underscores the critical role of veterinary professionals in early detection, diagnosis, and management of fungal diseases in wildlife and advocates for proactive strategies to mitigate their broader ecological and public health impacts.
Referências
Allender, M. C.; Raudabaugh, D. B.; Gleason, F. H.; Miller, A. N. The natural history, ecology, and epidemiology of Ophidiomyces ophiodiicola and its potential impact on free-ranging snake populations. Fungal Ecol., v. 17, p. 187–196, 2015.
Basanta, M. D.; Martel, A.; Pasmans, F. Emerging fungal pathogens in wildlife: current knowledge and future challenges. Front. Vet. Sci., v. 9, 891324, 2022.
Benício, R. A.; Toledo, L. F.; Becker, C. G.; Haddad, C. F. B. First evidence of high prevalence of Batrachochytrium dendrobatidis in semi-arid species. Trop. Conserv. Sci., v. 13, p. 1–9, 2020.
Blehert, D. S.; Hicks, A. C.; Behr, M. et al. Bat white-nose syndrome: an emerging fungal pathogen? Science, v. 323, n. 5911, p. 227, 2009.
Boyle, D. G. et al. Emergence of Nannizziopsis barbatae in free-living Australian reptiles. PLoS Pathog., v. 16, n. 11, e1008893, 2020.
Carvalho, T.; Becker, C. G.; Toledo, L. F. Historical amphibian declines in Brazil linked to chytridiomycosis. Proc. Biol. Sci., v. 284, n. 1853, 20162254, 2017.
Davy, C. M.; Donaldson, M. E.; Willis, C. K. R. White-nose syndrome is associated with increased replication of a naturally persisting coronavirus in bats. Biol. Lett., v. 14, n. 9, 20180490, 2018.
EFSA Panel on Animal Health and Welfare (AHAW). Risk of survival, establishment and spread of Batrachochytrium salamandrivorans (Bsal) in the EU. EFSA J., v. 16, n. 4, 5259, 2018.
Farrer, R. A. et al. Genomic innovations linked to infection strategies across emerging pathogenic chytrid fungi. Nat. Commun., v. 8, 14742, 2017.
Fisher, M. C.; Alastruey-Izquierdo, A.; Berman, J. et al. Tackling the emerging threat of antifungal resistance to human health. Nat. Rev. Microbiol., v. 20, p. 557–571, 2022.
Fisher, M. C.; Garner, T. W. J.; Walker, S. F. Global emergence of Batrachochytrium dendrobatidis and amphibian chytridiomycosis in space, time, and host. Annu. Rev. Microbiol., v. 64, p. 291–310, 2020.
Fisher, M. C.; Gurr, S. J.; Cuomo, C. A. et al. Threats posed by the fungal kingdom to humans, wildlife, and agriculture. mBio, v. 11, n. 3, e00449-20, 2020.
Fisher, M. C.; Gurr, S.; Gow, N. A. R. et al. Tackling emerging fungal threats to animal health, food security, and ecosystem resilience. Philos. Trans. R. Soc. B, v. 371, 20160332, 2016.
Fisher, M. C.; Henk, D. A.; Briggs, C. J. et al. Emerging fungal threats to animal, plant and ecosystem health. Nature, v. 484, n. 7393, p. 186–194, 2012.
Fisher, M. C. et al. A One Health roadmap towards understanding and mitigating emerging fungal antimicrobial resistance. npj Antimicrob. Resist., v. 2, n. 1, 2024.
Franklinos, L. H. V. et al. Emerging fungal pathogen Ophidiomyces ophiodiicola in wild European snakes. Sci. Rep., v. 7, 3844, 2017.
Frick, W. F.; Pollock, J. F.; Hicks, A. C. et al. An emerging disease causes regional population collapse of a common North American bat species. Science, v. 329, n. 5992, p. 679–682, 2010.
Frick, W. F.; Cheng, T. L.; Langwig, K. E. et al. Pathogen dynamics during invasion and establishment of white-nose syndrome explain mechanisms of host persistence. Ecology, v. 98, n. 3, p. 624–631, 2017.
Garcia-Solache, M. A.; Casadevall, A. Global warming will bring new fungal diseases for mammals. mBio, v. 1, n. 1, e00061-10, 2010.
Gibb, R. et al. Zoonotic host diversity increases in human-dominated ecosystems. Nature, v. 584, n. 7821, p. 398–402, 2020.
Grisnik, M.; Gray, M. J.; Piovia-Scott, J. et al. Incorporating caudate species susceptibilities and climate change into models of Batrachochytrium salamandrivorans risk in the United States. Biol. Conserv., v. 284, 110181, 2023.
Haddaway, N. R.; Page, M. J.; Pritchard, C. C.; McGuinness, L. A. PRISMA 2020: R package and ShinyApp for producing PRISMA 2020 compliant flow diagrams. Syst. Rev., v. 11, n. 1, 43, 2022.
Hui, M. et al. Emerging antifungal resistance: mechanisms and management strategies. Front. Cell. Infect. Microbiol., v. 14, 2024.
Jenkinson, T. S. et al. Amphibian-killing chytrid in Brazil comprises both locally endemic and globally expanding populations. Mol. Ecol., v. 25, n. 13, p. 2978–2996, 2016.
Lambertini, C. et al. Amphibian chytrid fungus in the Brazilian Amazon: prevalence, species richness and lineage diversity. Sci. Rep., v. 12, n. 1, 1489, 2022.
Langwig, K. E.; Frick, W. F.; Reynolds, R. et al. Host and pathogen ecology drive the seasonal dynamics of white-nose syndrome. Proc. R. Soc. B, v. 282, 20142335, 2015.
Lorch, J. M. et al. Snake fungal disease: an emerging threat to wild snakes. Philos. Trans. R. Soc. B, v. 371, 20150457, 2016.
Martel, A. et al. Batrachochytrium salamandrivorans sp. nov. causes lethal chytridiomycosis in amphibians. Proc. Natl. Acad. Sci. U.S.A., v. 110, n. 38, p. 15325–15329, 2013.
Martel, A.; Blooi, M.; Adriaensen, C. et al. Recent introduction of a chytrid fungus endangers Western Palearctic salamanders. Science, v. 346, n. 6209, p. 630–631, 2014.
Martel, A.; Blooi, M.; Pasmans, F. Transcontinental spread of the emerging amphibian pathogen Batrachochytrium salamandrivorans. Emerg. Infect. Dis., v. 26, n. 9, p. 2122–2124, 2020.
McClure, M. L.; Hranac, C. R.; Haase, C. G. et al. Projecting the compound effects of climate change and white-nose syndrome on North American bat species. Clim. Change Ecol., v. 3, 100047, 2022.
Müller, L.; Martel, A.; Praet, S.; Pasmans, F. Ophidiomycosis in a European snake: case report and review of literature. Vet. Rec. Case Rep., v. 6, n. 4, e000730, 2018.
Page, M. J. et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, v. 372, n. 71, 2021.
Peters, M. D. J. et al. Chapter 11: Scoping Reviews. In: Aromataris, E.; Munn, Z. (eds.). JBI Manual for Evidence Synthesis. Adelaide: JBI, 2020.
Rodriguez, D.; Becker, C. G.; Pupin, N. C.; Haddad, C. F. B.; Zamudio, K. R. Long-term endemism of the amphibian chytrid fungus Batrachochytrium dendrobatidis in the Brazilian Atlantic Forest. Mol. Ecol., v. 23, n. 4, p. 774–787, 2014.
Scheele, B. C. et al. Amphibian fungal panzootic causes catastrophic and ongoing loss of biodiversity. Science, v. 363, n. 6434, p. 1459–1463, 2019.
Sigler, L.; Hambleton, S.; Paré, J. A. Molecular characterization of reptile pathogens currently known as members of the Chrysosporium anamorph of Nannizziopsis vriesii complex. Mycologia, v. 105, n. 2, p. 469–492, 2013.
Thomas, P. et al. Point-of-care diagnostics for emerging wildlife fungal pathogens. EcoHealth, v. 21, n. 1, p. 25–36, 2024.
Ugochukwu, E. I.; Osakwe, O. N.; Oragwa, A. O.; Nnadi, N. E.; Onyekwere, E. C. Emerging fungal diseases of wildlife: diagnostic challenges and control strategies. Vet. World, v. 15, n. 3, p. 563–573, 2022.
Voyles, J. et al. Shifts in disease dynamics in a tropical amphibian assemblage are not due to pathogen attenuation. Science, v. 359, n. 6383, p. 1517–1519, 2018.
Waddle, A. W.; Refsnider, J. M.; Adams, C. et al. Global patterns of emerging fungal pathogens in reptiles. Fungal Ecol., v. 47, 100956, 2020.
Walker, D. M.; Raudabaugh, D. B.; Miller, A. N. Environmental DNA as a tool for monitoring fungal pathogens. Fungal Ecol., v. 54, 101115, 2022.
Wiederhold, N. P. Antifungal resistance: current trends and future strategies to combat. Infect. Dis. Clin. N. Am., v. 37, n. 2, p. 271–288, 2023.
Woodhams, D. C. et al. Antifungal isolates database of amphibian skin-associated bacteria and function against emerging fungal pathogens. Ecology, v. 101, n. 1, e02918, 2020.
Woods, M.; Ashraf, N.; Bromley, M. et al. A One Health approach to overcoming fungal disease and antifungal resistance. WIREs Mech. Dis., v. 15, e1610, 2023.
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