Effects of angiotensin II in the vascular system

Authors

  • Sílvia Manduca Trapp Universidade Norte do Paraná, UNOPAR, Paraná, PR
  • Maria do Carmo Fernandez Vailati FMVZ-Unesp, Botucatu
  • Beatriz Bojikian Matsubara Faculdade de Medicina de Botucatu, UNESP, Campus de Botucatu
  • Denise Saretta Schwartz Faculdade de Medicina Veterinária e Zootecnia, USP, São Paulo

DOI:

https://doi.org/10.5380/avs.v14i4.16042

Keywords:

angiotensina II, coração, hipertensão, vasos sanguíneos, angiotensin II, blood vessels, heart, hypertension

Abstract

Angiotensin is an important peptide of renin-angiotensin-aldosterone system. This peptide has an important function on arterial blood pressure regulation and body fluid homeostasis. However, its action on abnormal conditions causes deleterious effects on the cardiovascular system. Vascular resistance, hypertension, vascular and myocytes hipertrophy, production of free radicals and pro-inflammatory substances are some of the actions of angiotensin II that can result on cardiovascular remodeling. Angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptors antagonists, antiinflammatories and antioxidants are used clinically and/or experimentally to prevent or reduce the effects of angiotensin II. The purpose of this work is to review the actions and interactions of angiotensin II on the cardiovascular system, as well as the therapeutic measures employed for the control of these effects.

Author Biographies

Sílvia Manduca Trapp, Universidade Norte do Paraná, UNOPAR, Paraná, PR

Medicina Veterinária, CCHSETA, UNOPAR, Arapongas, PR

Maria do Carmo Fernandez Vailati, FMVZ-Unesp, Botucatu

Departamento de Clínica Veterinária

Clínica de Pequenos Animais

Beatriz Bojikian Matsubara, Faculdade de Medicina de Botucatu, UNESP, Campus de Botucatu

Departamento de Clínica Médica

Área de Cardiologia

Denise Saretta Schwartz, Faculdade de Medicina Veterinária e Zootecnia, USP, São Paulo

Departamento de Clínica Médica

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How to Cite

Trapp, S. M., Vailati, M. do C. F., Matsubara, B. B., & Schwartz, D. S. (2009). Effects of angiotensin II in the vascular system. Archives of Veterinary Science, 14(4). https://doi.org/10.5380/avs.v14i4.16042

Issue

Vol. 14 No. 4 (2009)

Section

Review articles

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