Calcium homeostasis markers of bone metabolism in feline hyperthyroidism - a review

Abstract

Hyperthyroidism is the most frequent endocrine disease in cats . It is a illness provoked
by the excess of circulating thyroid hormones. Hyperthyroidism causes alteration in bone metabolism with
predominance of activity resorption. The evaluation of bone metabolism can be made by measuring serum and
urinary markers of bone metabolism or bone mineral densitometry. Osteoblasts are responsible cells for bone
formation while the osteoclasts are for resorption. In physiological situation osteoblastic and osteoclastic
are in balance. Markers of bone formation express the osteoblastic activity and markers of the osseous
resorption the osteoclástica activity. Markers of bone turnover are important in the diagnosis and prognostic of
muscle-skeletal disease, as well as in the accompaniment of therapy. It is fundamental do carry on studies on the
influence of feline hyperthyroidism on markers of bone formation and resorption in bone turnover to comprise
pathophysiologic mechanism of bone alterations.