Rafael Rodrigues Camacho, Elizabeth Regina Carvalho, Evandro Zacché Pereira, Fabio Nelson Gava, Aparecido Antonio Camacho, Marlos Gonçalves Sousa


Inflammatory substances such as interleukins (IL), tumor necrosis factor alpha (TNF-α) and C-reactive protein (CRP) have been demonstrated to play a role in heart failure progression. The aims of this study were two-fold: to investigate the concentration of circulating cytokines in dogs with myxomatous mitral valve disease (MMVD) in different stages, and to assess the relationship between these substances and cardiac morphology and function. For this purpose, twelve dogs with MMVD (7 stage-B2; 5 stage-C) and nine healthy controls underwent a transthoracic echocardiogram and had their serum concentrations of IL-1β, 4, 6, 10, TNF-α and CRP assessed. Data was submitted to Shapiro-Wilk normality test, groups were compared with ANOVA or Krukal-Wallis test according to distribution, and correlation coefficients were obtained with Spearman test. The IL-1β levels were different (P: 0.0056) between groups. Also, a positive correlation existed between IL-1β and left ventricular end-diastolic diameter (R: 0.56), left atrium-to-aorta ratio (R: 0.63) and echocardiography congestion surrogates. Similarly, IL-4 exhibited moderate-to-strong positive correlation with parameters of cardiac remodeling and congestion, while IL-6 was negatively correlated with the shortening fraction (R: -0.49). As the main conclusion, IL-1β levels increases in dogs with MMVD, and even higher levels are observed in overtly symptomatic animals.


echocardiography; mitral insufficiency; heart failure; inflammation; interleukins

Texto completo:

PDF (English)


 Creative Commons License

BASE DE DADOSScopus  Sumário.Org  Google Scholar  BASE  Dimensions 

DIRETÓRIOS:  Open Air  Genamics  EZB  Diretório Luso brasileiro  ROAD  Latindex  REDIB  Journal 4-free 

PORTAIS:  LiVre  Capes  Science Open  World Wide Science 

ÍNDICES:  Index Copernicus  Cite Factor