Lesionally enriched skin microbiota transplantation by activated charcoal nose pore strips for ‘treat to target’ in canine pyoderma
DOI:
https://doi.org/10.5380/avs.v29i3.95663Palavras-chave:
Microbiota, skin, superficial pyoderma, transplantationResumo
Amaçlar: Birçok bakteri, farklı karbon kaynaklarının bir kombinasyonu arasındaki substratları seçici olarak kullanabilir. Aktif karbon, temel ilaçlar için bir konum sergiler ve gastrointestinal ve ermatolojik sorunlarla mücadelede rol oynar. Toksinlerin deriden uzaklaştırılması yoluyla probiyotik veya patojenik bakterilere karşı farklı etki mekanizmasını bildiren bir çalışma bulunmamaktadır. Yüksek adsorpsiyon kapasitesi, kimyasal stabilitesi ve mekanik sağlamlığı nedeniyle, aktif kömür burun gözenek şeritleri kullanılarak lezyonel olarak zenginleştirilmiş cilt mikrobiyota transplantasyonunun (Le-smt) köpeklerde piyodermaya karşı savaşabileceğini varsaydık. Metodoloji: Daha önce herhangi bir ilaç reçetesi olmayan, klinik ve laboratuvar muayenelerine tabi tutulan ve yüzeysel piyoderma tanısı alan toplam 16 köpek kaydedildi ve haftada 3 kez Le-smt aktif kömür burun gözenek şeritleri ile tedavi edildi. Köpekler arasında piyoderma için önceden belirlenmiş puanlama, Le-smt öncesinde (10 ila 61 arasında değişen) ve sonrasında (0 ila 22) benimsenmiştir. Bulgular: Haftada 3 seans sonunda 16 köpeğin tamamı herhangi bir ilaç reçetesi olmadan iyileştirildi. Le-smt ortalama yüzeysel piyoderma skorlamasına göre tedavi öncesinde ve tedavi sonrasında sırasıyla 37,10 ve 9,81 (p<0,001) olmuştur. Sonuç: Bu yeni teknik, eski moda tedavi protokolünü polifarmasi ile değiştirmeli ve muhtemelen onun yerine geçmelidir.
Referências
Ali, M.M., Newsom, D.L., González, J.F., Sabag-Daigle, A., Stahl, C., Steidley, B., Dubena, J., Dyszel, J.L., Smith, J.N., Dieye, J., Arsenescu, R., Boyaka, B.N., Krakowka, S., Romeo, T., Behrman, E.J., White, P.,
Ahmer, B. M. Fructose-asparagine is a primary nutrient during growth of Salmonella in the inflamed intestine. PLoS pathog, 10:(6);e1004209, 2014.
Annessi. Tufted folliculitis of the scalp: a distinctive clinicohistological variant of folliculitis decalvans. Br J Dermatol, 138:(5);799-805, 1998.
Burchacka, E., Łukaszewicz, M., Kułażyński, M. Determination of mechanisms of action of active carbons as a feed additive. Bioorg Chem, 93;102804, 2019.
Chew, S.C., Yang, L. Biofilms. In Encyclopedia of Food and Health. Academic Press: Oxford, UK, pp. 407–415, 2016.
Chiarini, C., Torchia, D., Bianchi, B., Volpi, W., Caproni, M., Fabbri, P. Immunopathogenesis of folliculitis decalvans: clues in early lesions. Am J Clin Pathol, 130:(4);526-534, 2008
Chu, G.M., Jung, C.K., Kim, H.Y., Ha, J.H., Kim, J.H., Jung, M.S., Lee, S.J., Song, Y., Ibrahım, R.S.H., Cho, J.H., Lee, S.S., Song, Y. M. Effects of bamboo charcoal and bamboo vinegar as antibiotic alternatives on growth performance, immune responses and fecal microflora population in fattening pigs. Anim Sci J, 84:(2);113-120, 2013.
Constantinou, A., Kanti, V., Polak-Witka, K., Blume-Peytavi, U., Spyrou, G.M., Vogt, A. The potential relevance of the microbiome to hair physiology and regeneration: the emerging role of metagenomics. Biomedicines, 9:(3); 236, 2021.
Dalvi, R.R., Ademoyero, A.A. Toxic effects of aflatoxin B1 in chickens given feed contaminated with Aspergillus flavus and reduction of the toxicity by activated charcoal and some chemical agents. Avian Dis, 61-69, 1984.
Dalvi, R.R., McGowan, C. Experimental induction of chronic aflatoxicosis in chickens by purified aflatoxin B1 and its reversal by activated charcoal, phenobarbital, and reduced glutathione. Poult Sci, 63:(3);485-491, 1984.
Faber, F., Thiennimitr, P., Spiga, L., Byndloss, M.X., Litvak, Y., Lawhon, S., Andrews-Polymenis, H.L., Winter, S.E., Bäumler, A. J. Respiration of microbiota-derived 1, 2-propanediol drives Salmonella expansion during colitis. PLoS pathog, 13:(1);e1006129, 2017.
Hsiao, Y.H., Imanishi, I., Iyori, K. Efficacy of olanexidine gluconate in canine superficial pyoderma: a randomised, single‐blinded controlled trial. Vet Dermatol, 32:(6);664-e174, 2021.
Imlay, J.A. Where in the world do bacteria experience oxidative stress?. Environ Microbiol, 21:(2); 521-530, 2019.
Iwasaki, T., Nagata, M., Ohmuro, T. Validation of a novel guideline for clinical trial of antimicrobials in canine bacterial pyoderma. Jpn J Vet Dermatol, 14;71-75, 2008.
Krasaekoopt, W., Bhandari, B., Deeth, H. The influence of coating materials on some properties of alginate beads and survivability of microencapsulated probiotic bacteria. Int Dairy J, 14:(8);737-743, 2004.
Lee, M.G., Joeng, H., Shin, J., Kim, S., Lee, C., Song, Y., Lee, B.H., Park, H.G., Lee, T.H., Jiang., H.H., Han, Y.S., Lee, B.G., Lee, H.J., Park, M.J., Jun, Y.J., Park, Y. S. Potential probiotic properties of exopolysaccharide-producing Lacticaseibacillus paracasei EPS DA-BACS and prebiotic activity of its exopolysaccharide. Microorganisms, 10:(12);2431, 2022.
Matard, B., Donay, J. L., Resche‐Rigon, M., Tristan, A., Farhi, D., Rousseau, C., Mercier-Delarue, S., Cavelier–Balloy, B., Assouly, P., Petit, A., Bagot, M., Reygagne, P. Folliculitis decalvans is characterized by a persistent, abnormal subepidermal microbiota. Exp Dermatol, 29:(3); 295-298, 2020.
Older, C. E., Rodrigues Hoffmann, A., Hoover, K., & Banovic, F. (2020). Characterization of cutaneous bacterial microbiota from superficial pyoderma forms in atopic dogs. Pathogens, 9(8), 638.
Otberg, N., Kang, H., Alzolibani, A.A., Shapiro, J. Folliculitis decalvans. Dermatol Ther, 21:(4);238-244. 2008.
Powell, J.J., Dawber, R.P.R., Gatter, K. Folliculitis decalvans including tufted folliculitis: clinical, histological and therapeutic findings. Br J Dermatol, 140:(2);328-333, 1999.
Rivera-Chávez, F., Zhang, L.F., Faber, F., Lopez, C.A., Byndloss, M.X., Olsan, E.E., Xu, G., Velazquez, E.M., Lebrilla, C.B., Winter, S.E., Bäumler, A.J. Depletion of butyrate-producing Clostridia from the gut microbiota drives an aerobic luminal expansion of Salmonella. Cell Host Microbe, 19:(4);443-454, 2016.
Rivera-Lugo, R., Deng, D., Anaya-Sanchez, A., Tejedor-Sanz, S., Tang, E., Ruiz, V.M.R., Smith, H.B., Titov, D.V., Sauer, J.D., Skaar, E.P., Ajo-Franklin, C.M., Partony, D.A., Light, S.H. Listeria monocytogenes requires cellular respiration for NAD+ regeneration and pathogenesis. Elife, 11;e75424, 2022.
Rivera‐Utrilla, J., Bautista‐Toledo, I., Ferro‐García, M.A., Moreno‐Castilla, C. Activated carbon surface modifications by adsorption of bacteria and their effect on aqueous lead adsorption. J Chem Technol Biotechnol, 76:(12);1209-1215, 2001.
Romick, T.L., Fleming, H.P., McFeeters, R.F. Aerobic and anaerobic metabolism of Listeria monocytogenes in defined glucose medium. Appl Environ Microbiol, 62:(1);304-307, 1996.
Salminen, H., Weiss, J. Electrostatic adsorption and stability of whey protein–pectin complexes on emulsion interfaces. Food Hydrocoll, 35;410-419, 2014.
Sands, D.C., McINTYRE, J.L., Walton, G.S. Use of activated charcoal for the removal of patulin from cider. Appl Environ Microbiol, 32:(3);388-391, 1976.
Sillani, C., Bin, Z., Ying, Z., Zeming, C., Jian, Y., Xingqi, Z. Effective treatment of folliculitis decalvans using selected antimicrobial agents. Int J Trichology, 2:(1);20, 2010.
Spiga, L., Winter, M. G., de Carvalho, T. F., Zhu, W., Hughes, E. R.,
Gillis, C. C., Behrendt, C.L., Kim, J., Chessa, D., Andrews-Polymenis, H.A., Beiting, D.P., Santos, R.L., Hooper, L.V., Winter, S. E. An oxidative central metabolism enables Salmonella to utilize microbiota-derived succinate. Cell Host Microbe, 22:(3);291-301, 2017.
Ural, K., Erdoğan, H., Erdoğan, S., Balıkçı, C. Unenriched skin microbiota transplantation for cats: new road story for treating feline atopic skin syndrome. Braz J Vet Med, 45;e002823, 2023a.
Ural, K., Erdogan, H., Erdogan, S. Skin microbiota transplantation by Nivea Refining Clear-Up Strips could reverse erythema scores in dogs with atopic dermatitis: Novel strategy for skin microbiome manuplation. Turkiye Klinikleri J Vet Sci, 2023;14(1),11–17, 2023b.
Ural K., Erdoğan H., Erdoğan S. Heterologue Skin Microbiota Transplantation for Treatment of Sarcoptic Manges in Two Dogs with Zoonotic Transmission. Bozok Vet Sci, 3:(2);52-56, 2022.
Winter, S.E., Thiennimitr, P., Winter, M.G., Butler, B.P., Huseby, D.L., Crawford, R.W., Russel, J.M., Bevins, C.L., Adams, L.G., Tsolis, R.M.,
Roth, J.R., Bäumler, A.J. Gut inflammation provides a respiratory electron acceptor for Salmonella. Nature, 467:(7314);426-429, 2010.
Winter, S.E., Winter, M.G., Xavier, M.N., Thiennimitr, P., Poon, V., Keestra, A. M., Laughlin, R.C., Gomez, G., Wu, J., Lawhon, S., Popova, I.E., Parikh, S.J., Adams, L.G., Tsolis, R.M., Stewart, V.J., Bäumler, A.J. Host-derived nitrate boosts growth of E. coli in the inflamed gut. Science, 339:(6120); 708-711, 2013.
Zotta, T., Parente, E., Ricciardi, A. Aerobic metabolism in the genus Lactobacillus: impact on stress response and potential applications in the food industry. J Ap Microbiol, 122:(4); 857-869, 2017.
Zotta, T., Ricciardi, A., Ianniello, R.G., Parente, E., Reale, A., Rossi, F., Lacumin, L., Comi, G., Coppola, R. Assessment of aerobic and respiratory growth in the Lactobacillus casei group. PLoS One, 9:(6); e99189, 2014.
Zotta, T., Ricciardi, A., Ianniello, R.G., Storti, L.V., Glibota, N.A., Parente, E. Aerobic and respirative growth of heterofermentative lactic acid bacteria: A screening study. Food Microbiol, 76; 117-127, 2018.
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Autores que publicam nesta revista concordam com os seguintes termos:
- Autores mantém os direitos autorais e concedem à revista o direito de primeira publicação, com o trabalho simultaneamente licenciado sob a Creative Commons - Atribuição 4.0 Internacional que permite o compartilhamento do trabalho com reconhecimento da autoria e publicação inicial nesta revista.
- Autores têm autorização para assumir contratos adicionais separadamente, para distribuição não-exclusiva da versão do trabalho publicada nesta revista (ex.: publicar em repositório institucional ou como capítulo de livro), com reconhecimento de autoria e publicação inicial nesta revista.
- Autores têm permissão e são estimulados a publicar e distribuir seu trabalho online (ex.: em repositórios institucionais ou na sua página pessoal) a qualquer ponto antes ou durante o processo editorial, já que isso pode gerar alterações produtivas, bem como aumentar o impacto e a citação do trabalho publicado.
