Open Journal Systems

IMUNOSENESCÊNCIA E SEU IMPACTO NA PRÁTICA MÉDICA. UM NOVO OLHAR PARA UM VELHO PROBLEMA.

Pedro G. Lorencetti, Kornelis S.M. van der Geest, Qi Wang, Elisabeth Brouwer, Annemieke M.H. Boots

Resumo


Introdução:O envelhecimento é um processo complexo que influencia todos os sistemas do corpo humano e seu impacto no sistema imune é chamado Imunosenescência. Essa condição é resultado de várias modulações imunológicas causadas por interações entre fatores genéticos e ambientais e é responsável por importantes condições clínicas em indivíduos idosos como alta prevalência de doenças infecciosas e autoimunes, neoplasias e menor eficácia de vacinas. Objetivo: Nesta revisão serão discutidos os problemas clínicos mais comuns na população idosa relacionados a Imunosenescência, e os novos achados da ciência básica relevantes a este tópico. Conclusão: A melhor compreensão da Imunosenescência é importante para prevenção de doenças comuns relacionadas à idade e para a promoção de um envelhecimento saudável.

Palavras-chave


Imunologia; Envelhecimento; Envelhecimento Celular

Texto completo:

PDF (English)

Referências


-United Nations, Department of Economic and Social Affairs, Population Division (2013). World Population Ageing 2013. ST/ESA/SER.A/348.

-Franceschi C, Bonafe M, Valensin S, Olivieri F, De Luca M, Ottaviani E, et.al. Inflamm-aging. An evolutionary perspective on immunosenescence.2000 Ann. N. Y. Acad. Sci. 908, 244–254.

- Boehm T, Swann JB. Thymus involution and regeneration: two sides of the same coin? Nat Rev Immunol. 2013 Nov;13(11):831-8

- Wang C, Liu Y, Xu LT, Jackson KJ, Roskin KM, Pham TD,et.al. Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires. J Immunol. 2014 Jan 15;192(2):603-11.

-Khan N, Shariff N, Cobbold M, Bruton R, Ainsworth JA, Sinclair AJ, Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals.J Immunol. 2002 Aug 15;169(4):1984-92.

- Yoshikawa TT. Epidemiology and unique aspects of aging and infectious diseases. Clin Infect Dis. 2000 Jun;30(6):931-3.

-Crowson CS, Matteson EL, Myasoedova E, Michet CJ, Ernste FC, Warrington KJ, et.al. The lifetime risk of adult onset rheumatoid arthritis and other inflammatory autoimmune rheumatic diseases. Arthritis Rheum. 2011 Mar;63(3):633-9

-Grubeck-Loebenstein B, Wick G. The aging of the immune system. Adv Immunol 2002; 80:243–84.

-DePinho RA: The age of cancer. Nature 2000, 408(6809):248-254.

- Baylis D, Bartlett DB, Syddall HE, Ntani G, Gale CR, Cooper C, et. al. Immune-endocrine biomarkers as predictors of frailty and mortality: a ten year longitudinal study in community dwelling older people. Age (Dordr). 2013 Jun;35(3):963-71. -8.

-Bruunsgaard H, Andersen-Ranberg K, Jeune B, Pedersen AN, Skinhøj P, Pedersen BK. A high plasma concentration of TNF-alpha is associated with dementia in centenarians. J Gerontol A Biol Sci Med Sci. 1999 Jul;54(7):M357-64.

-Ferguson FG, Wikby A, Maxson P, Olsson J, Johansson B. Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors J Gerontol A Biol Sci Med Sci. 1995 Nov;50(6):B378-82.

- Wikby, A.,Johansson, B.,Ferguson, F. The OCTO and NONA immune longitudinal studies: a review of 11 years studies of Swedish very old humans.2003. Adv. Cell Aging Gerontol. 13, 1–16.

- Wikby A, Maxson P, Olsson J, Johansson B, Ferguson FG. Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study Mech Ageing Dev. 1998 May 15;102(2 3):187-98.

-Strindhall J, Nilsson BO, Löfgren S, Erneurudh J,Pawelec G, Johansson B, et.al. No Immune Risk Profile among individuals who reach 100 years of age: findings from the Swedish NONAimmune longitudinal study. Exp Gerontol. 2007 Aug;42(8):753-61.

- Wikby A, Johansson B, Olsson J, Löfgren S, Nilsson BO, Ferguson F. Expansions of peripheral blood CD8 T- lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp Gerontol. 2002 Jan-Mar;37(2-3):445-53.

- Baylis D, Bartlett DB, Syddall HE, Ntani G, Gale CR, Cooper C, et.al. Immune-endocrine biomarkers as predictors of frailty and mortality: a 10-year longitudinal study in community-dwelling older people. Age (Dordr). 2013 Jun;35(3):963-71.

- Olivieri F, Rippo MR, Monsurrò V, Salvioli S, Capri M, Procopio AD, et.al. MicroRNAs linking inflamm-aging, cellular senescence and cancer. Ageing Res Rev. 2013 Sep;12(4):1056-68.

- Libby P, Okamoto Y, Rocha VZ, Folco E. Inflammation in atherosclerosis: transition from theory to practice. Circ J. 2010 Feb;74(2):213-20.

- Bartlett DB, Firth CM, Phillips AC, Moss P, Baylis D, Syddall H, et.al. The age-related increase in low grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection. Aging Cell. 2012 Oct;11(5):912-5.

- Lio D, Scola L, Crivello A, Colonna-Romano G, Candore G, Bonafè M. et.al. Gender-specific association between -1082 IL 10 promoter polymorphism and longevity. Genes Immun. 2002 Feb;3(1):30-3.

- van Exel E, Gussekloo J, de Craen AJ, Bootsma-van der Wiel A, Frölich M, Westendorp RG. Inflammation and stroke: the Leiden 85-Plus Study. Stroke. 2002 Apr;33(4):1135-8.

- Frasca D, Diaz A, Romero M, Landin AM, Blomberg BB.High TNF-α levels in resting B cells negatively correlate with their response. Exp Gerontol. 2014 Jun;54:116-22.

- van der Geest KS, Abdulahad WH, Chalan P, Rutgers A, Horst G, Huitema MG, et.al. Disturbed B cell homeostasis in newly diagnosed giant cell arteritis and polymyalgia rheumatica. Arthritis Rheumatol. 2014 Jul;66(7):1927-38.

- Blair PA, Norena LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR, et al. CD19_CD24hiCD38hi B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients. Immunity 2010;32:129–40.

-Duddy M, Niino M, Adatia F, Hebert S, Freedman M, Atkins H. Distinct effector cytokine profiles of memory and naïve human B cell subsets and implication in multiplesclerosis. J Immunol. 2007 May 15;178(10):6092-9.

- Daien CI, Gailhac S, Mura T, Audo R, Combe B, Hahne M, Morel J. Regulatory B10 cells are decreased in patients with rheumatoid arthritis and are inversely correlated with diseaseactivity. Arthritis Rheumatol. 2014 Aug;66(8):2037-46.

- Gomez CR, Boehmer ED, Kovacs EJ. The aging innate immune system. Curr Opin Immunol 2005; 17:457–62.

- Grewe M. Chronological ageing and photoageing of dendritic cells. Clin Exp Dermatol 2001; 26:608–12.

-Fagnoni FF, Vescovini R, Passeri G, et al. Shortage of circulating naïve CD8(+) T cells provides new insights on immunodeficiency in aging. Blood 2000; 95:2860–8.

Lazuardi L, Jenewein B, Wolf AM, Pfister G, Tzankov A, Grubeck- Loebenstein B. Age-related loss of naive T cells and dysregulation of T-cell/B-cell interactions in human lymph nodes. Immunology 2005; 114:37–43.

- Allman D, Miller JP. B cell development and receptor diversity during aging. Curr Opin Immunol 2005; 17:463–7.

- Appay V, Dunbar PR, Callan M, Klenerman P, Gillespie GM, Papagno L,et.al.. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med 2002; 8:379–85

- Haynes L, Eaton SM. The effect of age on the cognate function of CD4+ T cells. Immunol Rev 2005; 205:220–8.

- Frasca D, Riley RL, Blomberg BB. Humoral immune response and Bcell functions including immunoglobulin class switch are downregulated in aged mice and humans. Semin Immunol 2005; 17:378–84.

- Tullius SG, Milford E. Kidney allocation and the aging immune response. N Engl J Med. 2011; 364(14):1369–70.

-Vail A, Gore SM, Bradley BA, Easty DL, Rogers CA, Armitage WJ. Conclusions of the corneal transplant follow up study. Br J Ophthalmol. 1997; 81(8):631–6.

- Zetterman RK, Belle SH, Hoofnagle JH, Lawlor S, Wei Y, Everhart J, et al. Age and liver transplantation: a report of the Liver Transplantation Database. Transplantation. 1998; 66(4):500–6.

- Meier-Kriesche HU, Ojo AO, Cibrik DM, Hanson JA, Leichtman AB, Magee JC, et al. Relationship of recipient age and development of chronic allograft failure. Transplantation. 2000; 70(2):306–10.

- Tullius SG, Reutzel-Selke A, Bachmann U, Jurisch A, Nieminen-Kelha M, Pratschke J, et al. Influence of recipient and donor age on long-term renal allograft function in an experimental model. Transplant Proc. 2001; 33(7-8):3345–6.

- Schmidt, D., Martens, P. B., Weyand, C. M. & Goronzy, J. J. The repertoire of CD4+ CD28– T cells in rheumatoid arthritis. Mol Med. 1996 Sep;2(5):608-18.

- Koetz K, Bryl E, Spickschen K, O'Fallon WM, Goronzy JJ, Weyand CM.. T cell homeostasis in patients with rheumatoid arthritis. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9203-8.

- Boots AM, Maier AB, Stinissen P, Masson P, Lories RJ, De Keyser F. The influence of ageing on the development and management of rheumatoid arthritis.Nat Rev Rheumatol. 2013 Oct;9(10):604-13.




DOI: http://dx.doi.org/10.5380/rmu.v1i4.40693

DOI (PDF (English)): http://dx.doi.org/10.5380/rmu.v1i4.40693.g24938

Apontamentos

  • Não há apontamentos.