VEICULAÇÃO DE ÓLEOS ESSENCIAIS EM ÓVULOS VAGINAIS PARA O CONTROLE DE DOENÇAS INFECCIOSAS
Abstract
Pharmaceutical forms must be designed for the correct incorporation of active ingredients, taking into account their physicochemical characteristics, avoiding degradation and achieving efficient delivery. This study tested methods of incorporating essential oils with known antimicrobial activity into vaginal ovules developed with a gelatin-glycerin mucoadhesive polymer using two methods. The first method consists of a one-phase preparation at low temperature while the second divides the formulation into two phases at low temperature. The ovules containing essential oils were subjected to organoleptic analysis, pH verification and average weight and disintegration tests. The ovules prepared by the second method showed indications of correct incorporation and adequate pH, average weight and disintegration time for the pharmaceutical form.
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