DRUG-INDUCED LABORATORY CHANGES, WITH EMPHASIS ON THE MAIN BIOCHEMICAL MARKERS OF THE RENAL AND HEPATIC PROFILE: A REVIEW OF THE LITERATURE

Abstract

There are medicines, as products resulting from biotechnological advances, with curative, prophylactic, preventive and diagnostic purposes. With the practice of polypharmacy, the occurrence of drug interactions in laboratory tests becomes more susceptible, which can culminate in changes in several biochemical markers. Therefore, this work aimed to describe the main laboratory changes observed in biochemical tests, specifically in the renal and hepatic profile. A descriptive literature review was carried out, with a qualitative approach, through searches in the PubMed and Scielo databases, using a time frame from 2013 to 2023. After applying the inclusion and exclusion criteria, 35 articles were used to construct this work . Among the classes of medications that are most likely to cause liver damage are antibiotics, antineoplastics, antiepileptics, non-steroidal anti-inflammatory drugs and antituberculous drugs, causing changes in a variety of liver markers. The most relevant drug classes for nephrotoxicity are antibiotics, antiviral agents, non-steroidal anti-inflammatory agents and chemotherapy, resulting in changes in renal markers. In short, after analyzing the materials used to construct this article, we observed the recurrence of changes that medications can use in tests to evaluate kidney and liver functions.