Hepatoprotective treatment improves leukocyte responses of Wistar rats intoxicated by CCl4
Abstract
The aims of this investigation was to evaluate the effect of hepatoprotective treatments with a compound
prepared by the association of N-Acetyl DL-Methionine (5%) + Choline chloride (2%) + Caffeine (1%) +
Thiamine hydrochloride (1%) + Nicotinamida (0,5%)+ Pyridoxine hydrochloride (0.04%), administered
through intramuscular (IM) route, at doses of 0.2, 0.6 and 1.0 mL/kg of BW, through the study of leukocytes
responses in rats submitted to acute intoxication with CCl4. 147 females were randomized into 21 groups,performing five different treatments, which were evaluated seven animals in four periods: two, four, six and
eight days after CCl4-induced intoxication. In this study, it was observed absolute eosinophilia andmonocytosis in animals untreated and treated with the lowest dose of 0.2 mL. These responses were
significantly better in animals treated with 0.6 and 1.0 mL/ kg BW. The untreated animals showed
thrombocytopenia, when compared to treated animals. Absolute neutropenia and lymphocytosis was
observed in all rats intoxicated with CCl4, there is no difference among treatments. The analysis of white
blood cells demonstrated that the hepatoprotective treatments favored the leukocyte response, by act
beneficially on the population of these cells, supporting the hypothesis that these events may reduce the
deleterious effects in liver tissue after intoxication by CCl4.
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PDF (Português (Brasil))DOI: http://dx.doi.org/10.5380/avs.v14i2.12633