PREVALÊNCIA DE DOENÇA RENAL CRÔNICA EM PACIENTES HIV-POSITIVO ACOMPANHADOS NO HC-UFPR

Eduardo Henrique Bonotto, Gustavo Guerchon, Paulo Henrique Lazzaris Coelho, Clea Elisa Ribeiro, Marcelo Mazza do Nascimento

Resumo


Objetivo: Avaliar a prevalência de DRC em pacientes portadores de HIV em acompanhamento no ambulatório de infectologia em um Hospital Universitário de Curitiba. Métodos: Estudo transversal retrospectivo com análise de 396 prontuários de pacientes portadores de HIV entre 20 e 50 anos de idade acompanhados no ambulatório de Infectologia do Hospital de Clínicas da Universidade Federal do Paraná (HC-UFPR) no ano de 2013. Resultados: Foram encontrados 9 pacientes (2,3%) com ritmo de filtração glomerular estimado (RFGe) < 60 mL/min/1,73 m2 nas duas avaliações. Dos 108 pacientes que possuíam duas avaliações de proteinúria, 6 pacientes (1,5% do total) apresentavam proteinúria persistente. Dessa forma, 14 (3,5%) preencheram o critério diagnóstico para DRC. Entre os 194 pacientes (48,9%) que possuíam apenas uma avaliação de proteinúria, cerca de 44 pacientes (11,1% do total) apresentavam algum grau de proteinúria. Hipertensão arterial (p<0,0001) e dislipidemia (p=0,026) foram significativamente mais prevalentes nos pacientes com DRC. Além disso, houve uma correlação negativa e significativa entre RFGe e idade (r=-0,48; p<0,0001); tempo de tratamento com TARV (r=-0,12; p=0,04) e tempo de diagnóstico do HIV (r=-0,15; p=0,004). Finalmente, uma correlação positiva e significativa foi encontrada entre RFGe e CD4+ nadir (r=0,10; p=0,04).  Conclusão: Na amostra estudada foi encontrada uma prevalência de DRC de 3,5%, sendo que pacientes portadores de HIV com menores valores de CD4+ nadir e maior tempo de tratamento e de doença parecem apresentar um risco maior de desenvolver DRC.    


Palavras-chave


Doença Renal Crônica; Nefropatia Associada a AIDS; HIV.

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Referências


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DOI: http://dx.doi.org/10.5380/rmu.v4i4.50646

DOI (PDF): http://dx.doi.org/10.5380/rmu.v4i4.50646.g31704

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